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Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 293-300 doi: 10.1631/FITEE.1400282

Abstract: purification, and mass spectrometry high-throughput proteomic techniques supplies a large amount of protein-proteinResearch shows that overlapping complexes can contribute to identifying essential proteins, which areOMMR) is proposed to analyze the similarity between the identified overlaps and the benchmark overlap modulesComparison of essential proteins and gene ontology (GO) analysis are also used to assess the qualitycomprehensive comparison of serveral overlapping complexes prediction approaches, using three yeast protein-protein

Keywords： Protein-protein interaction network     Essential protein modules     Overlap     Overlap maximum matching ratio    

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expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: developed MPN phenotype in myelofibrosis (MF) and secondary AML (sAML) transformed from MPNs versus essential

Keywords： myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract: We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering.Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichmentEight distinct modules were identified by the WGCNA.Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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Isomorphism analysis on generalized modules oriented to the distributed parameterized intelligent product

Shasha ZENG, Weiping PENG, Tiaoyu LEI

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 12-23 doi: 10.1007/s11465-019-0555-9

Abstract: In this study, a new method of isomorphism analysis on generalized modules oriented to DPIPP is proposedSecond, similarity calculation of generalized modules is realized by improving the clustering using representativesGeneralized modules with a similar structure are combined to complete the isomorphism analysis.

Keywords： distributed parameterized intelligent product platform     generalized module     isomorphism analysis     product family    

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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

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Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 309-313 doi: 10.1007/s11684-008-0059-1

Abstract: assays were developed and performed for JAK2V617F detection on 40 polycythemia vera (PV) samples, 31 essential

Keywords： specific amplification     essential thrombocythemia     Single-tube bi-directional     JAK2V617F-positive     JAK2V617F    

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A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Strategic Study of CAE 2000, Volume 2, Issue 5,   Pages 66-71

Abstract:

This thesis took the three essential factors of forest fire (fire source, environment, and litter)

Keywords： forecast of forest fire     space remote sensing     essential factors of forest fire     a new way    

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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism and

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Engineering 2018, Volume 4, Issue 1,   Pages 9-10 doi: 10.1016/j.eng.2018.02.006

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Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 279-287 doi: 10.15302/J-FASE-2019267

Abstract: Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing qualityGluten provides the unique extensibility and elasticity of dough that are essential for various wheatBased on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein.

Keywords： wheat gluten     consensus motifs     disulfide bonds     SDS-unextractable polymeric protein     glutenins     gliadins     processing quality     storage protein    

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Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 1131-1139 doi: 10.1007/s11705-023-2321-0

Abstract: modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed, such that protein

Keywords： biomass     riboflavin sodium phosphate     silk protein     multifunctional modification     flame retardant    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Title Author Date Type Operation

Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Journal Article

expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Isomorphism analysis on generalized modules oriented to the distributed parameterized intelligent product

Shasha ZENG, Weiping PENG, Tiaoyu LEI

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Journal Article

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Journal Article

A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Journal Article

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Journal Article

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article